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This remarkable human ability poses a challenge for cognitive science. What are the brain mechanisms underlying higher-level cognitive functions? For a long time these have been wrapped up in a mystery. However, with the advance of cognitive neuroscience and cognitive psychological studies,the brain mechanisms underlying higher-level cognition are gradually being made explicit. This paper aims to explore these brain mechanisms underlying human thinking and inferences. This paper is organized as follows. First, I discuss the expansion of the prefrontal cortex and its functions in human brains. Secondly, the mechanisms of working memory are discussed with references to human symbolic thought and inferences. 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